The stylone ribbon like compacts, called ribblets, were compared with ribbons from a gerteis mini pactor regarding their sf. The gerteis mini pactor has a throughput of 10 grams per trial and up to 100kgh, allowing work in development, pilot plant, clinical and production. Formex llc acquires gerteis minipactor and korsch xl 100. Minipactor can process trial material batches as small as 10g but can easily be scaled up to small production runs, working at up to 100 kilograms per hour. By having the same diameter rollers as the larger macropactor, scaling up from development scale to. Housed within metrics main facility, the companys new gerteis mini pactor has capacity ranging from 10 grams for pilot projects to 100 kilograms per hour for smallscale production, making it especially useful in a formulation development laboratory setting, gold said. Pactor in the ham bands will continue to be used for qsos, but that use will continue to decline. This provides an ideal dry granulation platform for preclinical and clinical development, while at the same time easily handling pilot projects and smallscale production batches. It is an adaptive mode that applies different modulation and encoding methods depending on the channel quality. Pharmaceutical manufacturer penn pharma a pci company, today announced the successful installation of the gerteis mini pactor at its contained manufacturing facility. Pactor ii performs its initial link setup using pactor in order to achieve compatibility. Low bioavailability in poorly soluble drug candidates often results in suboptimal drug delivery.
Gerteis minipactor blending 1 100 kg scale tablet compression encapsulation coating feasibility batches 1 10 g development batches 100 g scaling gmp batches g 1 5 kghr hot melt extrusion capabilities related capabilities process selection. This roller compactor is the new standard in containment installations for dry granulation applications. The gerteis minipactor is the ideal laboratory roller compactor. S3 process were involved from the very beginning, from initial conceptual layout designs, through to project execution installation, acceptance testing and quali. The gerteis mini pactor allows optimization within a range of press forces, roller speeds, and gap settings using knurled, smooth, toothed or custom rollers with a production output of up to 100kghr. Gerteis premium roller compactors and dry granulation systems. Click cable reference link to determine correct cable to order for your radio. Gerteis offers elegant solutions in containment roll compaction from its standard oeb 3 models in the pactor range, up to oeb 5 models for very high containment, these can be integrated to fully automated cip skids from gerteis to fulfil a perfect cleaning and validation protocol. Additional options for the mini pactor include highcontainment solutions, an integrated 2step granulation system, separate feed funnel for small quantities, and an operator interface with industrial pc solutions. Professionalfirmware firmware with pactoriii, pactoripbridge, pactorfreesignal, robust connect and much more. Gerteis minipactor roller compactor system pharmaceutical. With its capacity of 10gtrial up to 100kghr, the minipactor is the ideal roller compactor for laboratory development. The gerteis minipactor, a topoftheline roller compactor, offers one of the best compaction technologies for producing dry granulated powders.
The gerteis custom isolator design achieves a containment level of machine setup, the production range lies between 10 gtrial up to 400 kgh. The minipactor is the ideal roller compactor for laboratory development. Aug 23, 2018 the remaining magnesium stearate was added extragranularly during blending subsequent to dry granulation. Pactor modem install the steps involved installation overview thankyou for purchasing your pactor modem from au your pactor modem can be used to send and receive email using your hf radio, to access weather information via your hf radio and also to plot your location on the net so that.
The lower compression roller is interchangeable with the unique gerteis granulating mill. The remaining magnesium stearate was added extragranularly during blending subsequent to dry granulation. The adjustable settings were the roller speed n r, the roller gap s and the specific compaction force scf. Additional options for the minipactor include high containment solutions, an integrated 2step granulation system. Metrics contract services adds two new roller compactors. The mini pactor s compaction capabilities will densify and improve poorflowing materials such as spray dried amorphous dispersions, and improve overall efficiency in the. Overview the laboratoryscale gerteis roller compactor, the minipactor system, has processing capacity ranging from 10 grams per trial up to 100kg per hour. Metrics contract services adds commercial gerteis roller. Control performance of different roll compactors pssrc. The obtained gap widths and the time required to achieve the steadystate processing condition are listed in table 3. The influence of roller compaction processing variables on the rheological properties of granules. When we moved our lab from san francisco to san rafael the gerteis mini pactor was the first piece of equipment installed in the pilot plant,recalls mark menning, phd, ceo of nucleo life sciences. Getting started with ham radio email 1997, 98 jim corenman ke6rk revised 16 jan 98 15z. Additionally, we proposed a simple method that uses the rc.
With the ptciiex, ptciiusb and ptciinet pactoriii operation is signallized by blinking of the pactoriiiled. Pactor can be viewed as a combination of two earlier digital modes, packet radio and amateur teleprinting over radio amtor. Macropactor roller compactor pharmaceutical online. The spray dryer is complemented by the companys purchase last year of a gerteis minipactor. The macropactor is the premium gerteis roller compactor with output capacity of up to 400kg per hour.
The use of pactor will increase, outside the ham bands. Purovaso with gerteis mini pactor here is an example of how purovaso can be used with the gerteis mini pactor as seen at achema in frankfurt this week. Metrics contract services has added a gerteis minipactor roller compactor to. Maintenance can be completed in one of the industrys fastest times, due to the unique polygran setup of individual machine parts. However, as a fully continuous granulation process, amounts from as little of 100g can also be dry granulated, making the macropactor suitable for development and pilot scale environments. Metrics contract services adds commercial gerteis roller compaction capabilities. The influence of roller compaction processing variables on. Additionally, the predictive accuracy of hybrid modeling, comparing the predicted sf with the measured sf of ribbons and ribblets was tested. Macropactor our flagship roller compactor is designed for development, pilot projects and fullscale production for the pharmaceutical, chemical and food industry. The influence of roller compaction parameters on granule. Scaleup to our full scare production machines is the fastest on the market due to our harmonized pactordesigns. Gerteis pharma technology focus issue 83 june 2019. Formex acquires gerteis minipactor and korsch xl 100. Capable of manufacturing solid, liquid, and semisolid dosage forms, bioduros drug product manufacturing team provides a comprehensive service for clinical trial material preparation in support of phase 0 to phase ii studies.
The version demonstrated in tokyo will feature a bilingual englishjapanese hmi and advanced washinplace capabilities. Penn pharma a pci company, installs new gerteis roller. It is designed to be nontechnical and human readable, and collectively describes use cases relating to a software system. Furthermore, the ability of the stylone evolution to mimic roll compaction correctly was tested. Formex acquires gerteis mini pactor and korsch xl 100 san diego, aug. Pdf modelbased approach to the design of pharmaceutical. In 2018, metrics added a second mini pactor to its granulation capabilities at its new stateoftheart, oral solid dose commercial manufacturing facility in greenville, north carolina, usa. Pactor provides improved throughput because its transmission speed adapts to the quality of the link and it uses huffman compressed characters. Pactor use will also decline for automailboxes as cheaper software alternatives are adopted. Evaluation of the performance of different types of roll.
Us patent for tablet formulation comprising semaglutide and a. Birmingham, micro pactor at pfizer and pilot scale mini pactor from gerteis on the attributes of drygranulated formulations, including the key properties of ribbons, characteristics of postmilling granules, and to explore the powder behaviour during roller compaction using numerical computations. Our smallest roller compactor, the minipolygran hits the perfect balance between performance and flexibility for placement within the laboratory. This document is intended as a guide for the mobile ham who is new to the world of message forwarding via the ham radio hf pactor network. Pactor radio equipment consists of an hf transceiver, a computer and a terminal node controller. Minipactor, roller compactor the minipactor roller compactor is designed for both laboratory development and for small to medium scale production runs, and is the most capable rollercompactor available on the market. The minipactor roller compactor is designed for both laboratory development and for small to medium scale production runs. Mansaroll compaction of pharmaceutical excipients and prediction using intelligent software ph. Roller compaction is a fully continuous granulation technology. Manufacturer of lproline, mini polygran, macro pactor, glass steel hybrid vessels and vibrating mixers offered by uventis bioscience, pune, maharashtra. Ru2600440c2 solid compositions containing agonist to glp. It was a great unit in its day, but i sold mine years ago and dont miss it one bit.
Juniper pharma services continues investment in oral solid. Formex llc acquires gerteis minipactor and korsch xl 100 published. Having the proper equipment in our facility allows us to perform our prototyping then produce gmp supplies using the same equipment. This investment in new contained roller compaction technology will further expand its service offering at the award winning site in south wales. The gerteis mini pactor, a topoftheline roller compactor, offers one of the best compaction technologies for producing dry granulated powders. The process is easily scaleable, facilitating shorter and less costly development programmes. Gherkin is the language that cucumber uses to define test cases. Aaron equipment buys, sells, and trades used gerteis roller compactor, model mini pactor. Dry granulation expert gerteis is attracting significant interest in its worldclass roller compaction technologies at the pmec indi.
Dry granulation was carried out by roller compaction on a gerteis mini pactor using smooth rolls, a 0. Software running on the computer drives the terminal node controller. The gerteis minipactor is the ideal laboratory roller compactor solution, designed and engineered for preclinical and clinical dry granulation development and pilot projects. A pair of smooth compaction rolls with 25 cm in diameter and 2. Drug product manufacturing, cgmp manufacturing services. This is a complete list of hardware and software supplied with the. The roller diameter was 25 cm and the roller width was 2. The most commonly used amateur program for this purpose is airmail.
Amorphous solid dispersions, bioavailability enhancement bd. Accessories 5 accessories for the scs ptc series the following accessories are available. A22 in zone 10, home of the pmec pharma machinery show. At the same time the machine can easily handle pilot projects and small scale production batches. There are a range of approaches to enhancing solubility, but amorphous solid dispersions are a sophisticated solution because they provide increased bioavailability, have applications across the drug discovery and development process and are highly suitable. The gerteis mini pactor offers a patented, proven design that enhances powder flow as well as effective containment using skan isolator technology and integrated cleaning systems. Hybrid modeling of roll compaction processes with the styl. Modelbased approach to the design of pharmaceutical roller. Submit a quote for this roll compactors or call 6303502200 for more information. Roller compaction, granulation and capsule product. Multiple press roller surfaces smooth, knurled, power grip granulator. The gerteis roller compactors are your reliable tools for the entire lifecycle of your solid dosage products. Pactor ii is a fully backwardcompatible improvement to the original pactor system. The correction factor kp for the mini pactor was determined.